Damp granulation in high shear granulators is the most commonly used procedure in the pharmaceutical industry to make a varied mix of fine powders into uniform granules, which are larger and denser and have the appropriate compactability and fluidity properties, in a short process time and with high reproduction.

MIC GRANULATORS

The MIC - DEVELOPER Granulator was designed for the development of new products, and also for the production of products with small batch sizes. MIC granulator capacities range between 1 and 10 litres, with interchangeable receptacles.

The MIC-PRODUCTION Granulator was designed for damp mixing and granulation processes, using fewer binders, and achieves very short mixing, blending and granulation times. MIC-Production granulator capacities range from 25 to 1,000 litres.

MIXING

The mixture of powders or granulated materials is a very important unitary operation in the pharmaceutical Industry, which aims to achieve uniformity of content (UC) in each of the components making up the mixture, so that the subsequent production stages (compression, filling of capsules or pellets, etc.) take place without any problems and produce dosage units with the right contents.

DVC AND MPY MIXERS

The DVC Developer is an interchangeable biconical mixer. Its structure enables it receptacles of different shapes to be interchanged, such as biconical and V-shaped containers, bins and barrels, and various capacities (10, 25 and 50 and 75 litres) with the same shape, for mixing at different speeds, enabling the combination of various shapes.

The DVC / MPY Production use a gentle and fluid mixing principle, moving the particles in equal proportions using the force of gravity, enabling solids to be mixed within between 5 and 15 minutes, depending on the type of mixture to be undertaken.

Its design and finish enable swift unloading and cleaning. It has an internal intensifier to help the mixing process. The mixers have capacities of between 50 and 3,000 litres.

BINS AND BARREL MIXER

BINS mixing system, BVN model, suitable for load capacities of between 150 and 1,500 total litres (50% useful volume). The equipment has a support chassis, housing a transmission turret system, gear motor and couplings. It also has a base for housing and anchoring the mixing bin. This support base has two side supports angled 90° apart to anchor the bin.

CALIBRATION

CPS DEVELOPER

The versatility of the CPS is due to the possible combination of the 5 controllable variables in a single configuration for each type of material to be calibrated:

Drive speed

Drive shape

Size and shape of the selection cone orifices

Distance between the wall of the drive and the wall of the selection cone

Total area of orifices in the selection cone. The CPS Developer has been designed to contribute to the development of new products in the laboratory.

Its advantages include:

• Less fine material generated.
• Easy to dismantle, and quick and easy to clean.
• Various sieves with a circular or square mesh.

CPH Production is ideal for reducing the size of dry or damp granulated materials, for pre-treatment of raw materials, and for dispersing ingredients or excipients, and also for the recovery of products failing to meet specifications. It can be completely dismantled (including the electric panel) for easy cleaning.

Fluid bed drying is a technology used very often in the pharmaceutical industry due to its efficiency in drying granulated materials obtained using a wet granulator. Their working principle is based on the drying process of the granulated material with the combination of the migration of the humidity from within the solid to the exterior by hot air and extracting this humidity by convection.

The equipment can also be fitted for Top Spray granulation and optionally for covering pellets using wurster technology.

ESSICCA Developer fluid bed dryer

Enables specific fluid bed drying programmes to be established for each product. They are executed from the operating panel by the necessary commands and controllers, and as a result the usual problems in the development of the process and establishment of the programme, such as the formation of air passage channels, lack of uniformity when drying the mass, localised overheating of the granulated material or erosion of the granulated material during drying are avoided.

Capacity of 10 litres

ESSICCA Production fluid bed dryer

Commanded by PLC, providing a control of air flow and temperature, and all the parameters necessary to optimise drying time and protect the granulated material from wear. The main body of the fluid bed dryer is designed to withstand an explosion pressure of 10 bar.

Capacity from 50 to 800 litres